Crock Pot Mississippi Meatloaf has been my go-to recipe for a comforting, home-cooked meal that requires minimal effort. This slow-cooker dish is tender, juicy, and bursting with ranch, au jus, and pepperoncini flavors, making it a savory and slightly tangy comfort food that delights everyone at the table. Whether you’re planning a family dinner or meal prepping for the week, this meatloaf is a reliable choice that doesn’t skimp on flavor. Let’s dive into how to make this mouthwatering dish!
Why You’ll Love This Crock Pot Mississippi Meatloaf
This Crock Pot Mississippi Meatloaf recipe is perfect for several reasons. First, it’s incredibly easy to make, allowing you to enjoy a delicious meal with minimal prep. The unique combination of ranch seasoning, au jus gravy, and pepperoncini peppers results in a flavor profile that’s hard to beat. Additionally, this recipe is gluten-free, making it suitable for various dietary needs. If you’re searching for the best Crock Pot meatloaf recipe, look no further. It’s also a fantastic option for leftovers, as the flavors deepen and improve over time. With a cooking time of 6 to 7 hours on low, this dish fits seamlessly into your busy schedule.
Ingredients for Crock Pot Mississippi Meatloaf
Gather these items:
- 2 lbs ground beef (or half beef, half pork)
- 1 cup breadcrumbs
- 2 large eggs
- ½ cup milk
- 1 packet ranch seasoning mix
- 1 packet au jus gravy mix
- ½ cup chopped pepperoncini peppers
- ¼ cup pepperoncini juice
- 1 teaspoon garlic powder
- ½ teaspoon onion powder
- ½ teaspoon black pepper
- 2 tablespoons butter (sliced for topping)
- Extra pepperoncini slices (for topping)
How to Make Crock Pot Mississippi Meatloaf Step-by-Step
- Step 1: Combine ground beef, breadcrumbs, eggs, milk, ranch seasoning mix, au jus gravy mix, chopped pepperoncini peppers, pepperoncini juice, garlic powder, onion powder, and black pepper in a large bowl. Mix gently until just combined.
- Step 2: Shape the mixture into a loaf and place it on parchment or foil inside the crock pot. Use foil balls to slightly lift the meatloaf if desired.
- Step 3: Top the meatloaf with sliced butter and extra pepperoncini slices.
- Step 4: Cover and cook on LOW for 6 to 7 hours or on HIGH for 3 to 4 hours until the internal temperature reaches 160°F (71°C).
- Step 5: Let the meatloaf rest for 10 minutes before slicing.
- Step 6: Serve with mashed potatoes, green beans, or rice, spooning juices over the top.
Pro Tips for the Best Crock Pot Mississippi Meatloaf
Keep these in mind:
- Use a mix of ground beef and pork for extra flavor and moisture.
- Let the meatloaf rest after cooking to retain moisture.
- For a spicier kick, add more pepperoncini or even some diced jalapeños.
- This dish is a simple Crock Pot meatloaf with pepperoncini that can be easily customized!
Best Ways to Serve Crock Pot Mississippi Meatloaf
This Mississippi-style meatloaf pairs wonderfully with classic sides. Serve it with creamy mashed potatoes for a comforting meal, or accompany it with steamed green beans for a pop of color and nutrition. For a heartier option, pair it with fluffy rice to soak up the savory juices. You can also slice the meatloaf and serve it in a sandwich with your favorite condiments for a delicious twist!

How to Store and Reheat Crock Pot Mississippi Meatloaf
To store leftover meatloaf, wrap it tightly in plastic wrap or aluminum foil and place it in the refrigerator. It will keep well for up to 3 days. To reheat, slice the meatloaf and place it in the microwave or reheat in a skillet over medium heat. You can also add a splash of beef broth or the reserved pepperoncini juice for added moisture.
Frequently Asked Questions About Crock Pot Mississippi Meatloaf
What’s the secret to perfect Crock Pot Mississippi Meatloaf?
The secret lies in the combination of ranch seasoning and au jus gravy mix, which infuses the meatloaf with rich flavors. Also, cooking it low and slow ensures the meatloaf stays moist and tender.
Can I make Crock Pot Mississippi Meatloaf ahead of time?
Yes! You can prepare the meatloaf mixture a day in advance and store it in the refrigerator until you’re ready to cook. Just remember to adjust the cooking time if it’s cold when placed in the crock pot.
How do I avoid common mistakes with Crock Pot Mississippi Meatloaf?
One common mistake is overmixing the meatloaf mixture, which can lead to a dense texture. Mix just until combined, and ensure you use the right amount of moisture, especially if you’re using lean meat.
Variations of Crock Pot Mississippi Meatloaf You Can Try
Feel free to experiment with different flavors! You can make a Mississippi meatloaf with Italian dressing for a zesty twist or incorporate different vegetables like grated carrots or chopped onions for added nutrition. Another option is to top it with a homemade gravy for an extra layer of flavor. You can also try substituting ground turkey for a leaner option, making this dish adaptable to your dietary needs.

For more delicious recipes, check out Chicken Bacon Ranch Pasta or Creamy Pepperoncini Chicken Skillet. If you’re interested in dessert, don’t miss our Sugar Plum Shortbread Cookies.
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Crock Pot Mississippi Meatloaf: 7 Savory Secrets
- Total Time: 405 minutes
- Yield: 8 servings 1x
- Diet: Gluten Free
Description
This slow-cooker Mississippi meatloaf is tender, juicy, and bursting with ranch, au jus, and pepperoncini flavors, offering a savory and slightly tangy comfort meal.
Ingredients
- 2 lbs ground beef (or half beef, half pork)
- 1 cup breadcrumbs
- 2 large eggs
- ½ cup milk
- 1 packet ranch seasoning mix
- 1 packet au jus gravy mix
- ½ cup chopped pepperoncini peppers
- ¼ cup pepperoncini juice
- 1 teaspoon garlic powder
- ½ teaspoon onion powder
- ½ teaspoon black pepper
- 2 tablespoons butter (sliced (for topping))
- Extra pepperoncini slices (for topping)
Instructions
- Combine ground beef, breadcrumbs, eggs, milk, ranch seasoning mix, au jus gravy mix, chopped pepperoncini peppers, pepperoncini juice, garlic powder, onion powder, and black pepper in a large bowl. Mix gently until just combined.
- Shape the mixture into a loaf and place it on parchment or foil inside the crock pot. Use foil balls to slightly lift the meatloaf if desired.
- Top the meatloaf with sliced butter and extra pepperoncini slices.
- Cover and cook on LOW for 6 to 7 hours or on HIGH for 3 to 4 hours until internal temperature reaches 160°F (71°C).
- Let the meatloaf rest for 10 minutes before slicing.
- Serve with mashed potatoes, green beans, or rice, spooning juices over the top.
Notes
- Prep Time: 15 minutes
- Cook Time: 6 to 7 hours on LOW or 3 to 4 hours on HIGH
- Category: Main Dish
- Method: Slow Cooker
- Cuisine: American
Nutrition
- Serving Size: 1 slice
- Calories: 450
- Sugar: 2g
- Sodium: 800mg
- Fat: 30g
- Saturated Fat: 12g
- Unsaturated Fat: 18g
- Trans Fat: 0g
- Carbohydrates: 20g
- Fiber: 1g
- Protein: 30g
- Cholesterol: 120mg
